I've practiced drills with right and left hand... I'm a righty normally but I don't find any of the controls on my 226 overly difficult to manipulate entirely with my left hand. then again, I have small hands, so things aren't that far to reach or scrunch up if I'm using my left.
If you have larger hands or longer fingers, manipulating the decocker or the mag release can be tricky.
It's probably coincidence tank ended up with 3 pistols from small handed lefties. :P
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